dexamethasone (Decadron, Maxidex, AK-Dex, Ozurdex)

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Introduction

Tradenames: Decadron, Maxidex, AK-Dex.

Indications

Dosage

Systemic agent:

Tabs: 0.25, 0.5, 0.75, 1.0, 1.5, 2, 4, 6 mg.

Elixir: 0.5 mg/5 mL.

Injection: 8 & 16 mg/mL (dexamethasone acetate) (5 mL)

Vitreal implant for treatment of macular edema: Ozurdex

Topical agent: 0.1% cream BID. Soluble in EtOH, insoluble in H2O. Nasal preparation: 2 sprays BID/TID.

Ophthalmic: ointment: (0.1%) BID-QID solution: 1 drop every 1-6 hours (1%)

Pharmacokinetics

elimination via liver

1/2life = 3.0 hours

protein binding = 68 %

Adverse effects

Drug interactions

Mechanism of action

More general terms

Additional terms

Component of

References

  1. Merck Index 11th ed #8116
  2. Research Biochemicals International 1993-94 catalog
  3. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  4. Jump up to: 4.0 4.1 4.2 4.3 Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  5. Jump up to: 5.0 5.1 5.2 5.3 5.4 Kaiser Permanente Northern California Regional Drug Formulary, 1998
  6. Jump up to: 6.0 6.1 Journal Watch 24(14):113, 2004 Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I, Zernak C, Danner K, Jokela R, Pocock SJ, Trenkler S, Kredel M, Biedler A, Sessler DI, Roewer N; IMPACT Investigators. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med. 2004 Jun 10;350(24):2441-51. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15190136
  7. Jump up to: 7.0 7.1 Deprecated Reference
  8. Jump up to: 8.0 8.1 Medical Knowledge Self Assessment Program (MKSAP) 17, 18 American College of Physicians, Philadelphia 2015, 2018
  9. Jump up to: 9.0 9.1 9.2 Corcoran TB et al. Dexamethasone and surgical-site infection. N Engl J Med 2021 May 6; 384:1731 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33951362 https://www.nejm.org/doi/10.1056/NEJMoa2028982

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