prostaglandin

Introduction

Naturally-occuring prostaglandins include:

• PGE1
• PGF1-alpha
• PGF2
• FGF2-alpha
• PGG2
• PGH2
• PGI2
• thromboxane A2
• thromboxane B2
• PGA1
• PGA2
• 19-alpha-OHPGA1
• 19-alpha-OHPGA2
• PGB1
• PGB2
• 19-alpha-OHPGB2
• PFB3
• PGF3-alpha

Function

• diverse functions depending upon tissue
• alters blood pressure in arterial smooth muscle
• induces labor in uterine muscle
• increases motility in lower GI tract
• induces bronchial contraction & bronchospasm in bronchial smooth muscle
• increases coagulability in platelets
• increases permeability in capillaries
• increases gastric acid secretion in stomach
• inhibits triglyceride hydrolysis in adipose tissue

Expression

• synthesized at the site of action
• made in nearly all tissues
• half life in seconds

More general terms

• fatty acid, unsaturated
• hormone

More specific terms

• prostaglandin A
• prostaglandin B
• prostaglandin D
• prostaglandin E
• prostaglandin endoperoxide
• prostaglandin F
• prostaglandin I (prostacyclin, epoprostenol {Flolan})
• prostaglandin J
• prostaglandin J2
• thromboxane

Additional terms

• cyclooxygenase cascade
• prostaglandin in body fluid
• prostaglandin receptor
• resolvin

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?