prostaglandin I (prostacyclin, epoprostenol {Flolan})
Jump to navigation
Jump to search
Introduction
[For molecular structure, see specific subtype in arachidonate, eicosapentaenoate, or eicosatrienoate cascade.]
Indications
- IV infusion for pulmonary hypertension
- treatment of digital ischemia associated with severe Raynaud's disease
Mechanism of action
- produced by cyclooxygenase-2 in vascular endothelium
- vasodilator
- inhibits platelet aggregation
More general terms
More specific terms
Additional terms
- cyclooxygenase cascade
- prostacyclin receptor; prostanoid IP receptor; PGI receptor; prostaglandin I2 receptor (PTGIR, PRIPR)
References
- ↑ Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999
- ↑ Prescriber's Letter 9(5):25-26 2002
- ↑ Journal Watch 22(10):78, 2002 Cheng Y et al Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 296:539, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11964481
Vane JR Biomedicine. Back to an aspirin a day? Science 296:474, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11964462