prostacyclin receptor; prostanoid IP receptor; PGI receptor; prostaglandin I2 receptor (PTGIR, PRIPR)

Function

• receptor for prostacyclin (prostaglandin I2 or PGI2)
• activity is mediated by Gs proteins which activate adenylate cyclase

Structure

• palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to Gs & signaling
• isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase & phospholipase C
• belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

More general terms

• G-protein coupled receptor; serpentine receptor
• prostaglandin receptor
• glycoprotein
• prenyl protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5739
• OMIM: https://mirror.omim.org/entry/600022
• UniProt: http://www.uniprot.org/uniprot/P43119.html