adenyl cyclase, adenylyl cyclase or adenylate cyclase
Jump to navigation
Jump to search
Introduction
The concept of signal transduction or signalling of extracellular signalling through 2nd messengers originated with the discovery of the role of cAMP
Function
- the adenyl cyclase/cAMP-dependent protein kinase pathway mediates hormonal control of many cellular cascades including
- glycogenolysis
- lipolysis
- catecholamine synthesis
- adenyl cyclases are activated through:
- Gs-alpha generated by serpentine receptor-mediated Gs protein dissociation
- protein kinase C
- Ca+2/Calmodulin
- G-beta/gamma
- nearly all of the 8 cloned adenyl cyclases are regulated via interactions with the PLC pathway[2]
- adenyl cyclases appear to be associated with Ca+2 channels
- Ca+2 inhibition of adenyl cyclases is predicted to result in oscillations of cAMP levels
- affinity for Mg+2 increases 20-fold upon activation by Gs-alpha-GTP
More general terms
- guanine nucleotide regulatory protein [GNRP] effector
- lyase
- plasma membrane protein
- transmembrane 12 protein
More specific terms
- adenyl cyclase-1 (ADCY1, Ca+2/calmodulin-activated adenyl cyclase)
- adenyl cyclase-2 (ATP pyrophosphate-lyase 2, ADCY2, KIAA1060)
- adenyl cyclase-3 (ATP pyrophosphate-lyase 3, adenylyl cyclase 3, adenylate cyclase olfactive type, ADCY3)
- adenyl cyclase-4 ( ATP pyrophosphate-lyase 4, ADCY4)
- adenyl cyclase-5 (ATP pyrophosphate-lyase 5, ADCY5)
- adenyl cyclase-6 (ATP pyrophosphate-lyase 6, ADCY6, KIAA0422)
- adenyl cyclase-7 (ATP pyrophosphate-lyase 7, ADCY7, KIAA0037)
- adenyl cyclase-8 (ADCY8, Ca+2/calmodulin-activated adenyl cyclase, ATP pyrophosphate-lyase 8)
- adenyl cyclase-9 (ATP pyrophosphate-lyase 9, ADCY9, KIAA0520)
- adenylate cyclase type 10 (testicular soluble adenylyl cyclase, germ cell soluble adenylyl cyclase, sAC, hsAC, adenylate cyclase homolog, AH-related protein, ADCY10, SAC)
- B. anthracis edema factor (EF)
- cyclolysin
Additional terms
- adenylyl cyclase-associated protein 1; CAP-1 (CAP1, CAP)
- adenylyl cyclase-associated protein 2; CAP-2 (CAP2)
References
- ↑ White & Hartzell Biochem Pharmacol 38:859 1990
- ↑ 2.0 2.1 Cooper et al Adenylyl cyclases and the interaction between calcium and cAMP signalling. Nature 374:421 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7700350