adenyl cyclase-2 (ATP pyrophosphate-lyase 2, ADCY2, KIAA1060)

Function

• membrane-bound, calmodulin-insensitive adenylyl cyclase
• insensitive to Ca+2/calmodulin
• stimulated by protein kinase C, Gs-alpha[GTP] & G-beta/gamma (putative)

ATP <--> 3',5'-cyclic AMP + diphosphate

Cofactor: binds 2 Mg+2 per subunit (putative)

Structure

• belongs to the adenylyl cyclase class-4/guanylyl cyclase family
• contains 2 guanylate cyclase domains

Compartment

membrane

Expression

• expressed in brain
• richest source is cerebellum

More general terms

• adenyl cyclase, adenylyl cyclase or adenylate cyclase
• glycoprotein
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:108
• OMIM: https://mirror.omim.org/entry/103071
• UniProt: http://www.uniprot.org/uniprot/Q08462.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=108