adenyl cyclase-4 ( ATP pyrophosphate-lyase 4, ADCY4)

Function

• membrane-bound, calmodulin-insensitive adenylyl cyclase (putative)
• unaffected by Ca+2/calmodulin or protein kinase C
• stimulated by Gs-alpha[GTP] & G-beta/gamma (putative)

ATP <--> 3',5'-cyclic AMP + diphosphate

Cofactor: binds 2 Mg+2 per subunit (putative)

Structure

• belongs to the adenylyl cyclase class-4/guanylyl cyclase family
• contains 2 guanylate cyclase domains

Compartment

membrane

Expression

not expressed in large amounts in any tissue

More general terms

• adenyl cyclase, adenylyl cyclase or adenylate cyclase
• transmembrane 12 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1968
• OMIM: https://mirror.omim.org/entry/600292
• UniProt: http://www.uniprot.org/uniprot/Q8NFM4.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=196833