adenyl cyclase-1 (ADCY1, Ca+2/calmodulin-activated adenyl cyclase)

Function

• calmodulin-sensitive adenylyl cyclase
• may be involved in regulatory processes in the central nervous system
• may play a role in memory acquisition & learning
• activated by Ca+2/calmodulin
• Gs-alpha[GTP] is only mildly stimulatory
• inhibited by G-beta/gamma

ATP <--> 3',5'-cyclic AMP + diphosphate

Cofactor: binds 2 Mg+2 per subunit (putative)

Structure

• belongs to the adenylyl cyclase class-4/guanylyl cyclase family
• contains 2 guanylate cyclase domains

Compartment

membrane

Expression

• brain, retina & adrenal medulla
• richest sources are the dentate gyrus & hippocampus

More general terms

• adenyl cyclase, adenylyl cyclase or adenylate cyclase
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:107
• OMIM: https://mirror.omim.org/entry/103072
• UniProt: http://www.uniprot.org/uniprot/Q08828.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=107