adenyl cyclase-9 (ATP pyrophosphate-lyase 9, ADCY9, KIAA0520)

Function

• may play a fundamental role in situations where fine interplay between intracellular Ca+2 & cAMP determines cellular function
• may be a physiologically relevant docking site for calcineurin (putative)
• insensitive to Ca+2/calmodulin, forskolin & somatostatin
• stimulated by beta-adrenergic receptor activation

ATP <--> 3',5'-cyclic AMP + diphosphate

Cofactor: binds 2 Mg+2 per subunit

Structure

• belongs to the adenylyl cyclase class-4/guanylyl cyclase family
• contains 2 guanylate cyclase domains

Compartment

membrane

Expression

• expressed in multiple cells of the lung
• expression highest in airway smooth muscle

More general terms

• adenyl cyclase, adenylyl cyclase or adenylate cyclase
• phosphoprotein
• glycoprotein
• transmembrane 12 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:115
• OMIM: https://mirror.omim.org/entry/603302
• UniProt: http://www.uniprot.org/uniprot/O60503.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=115