adenyl cyclase-8 (ADCY8, Ca+2/calmodulin-activated adenyl cyclase, ATP pyrophosphate-lyase 8)

Function

• membrane-bound, Ca+2-stimulable adenylyl cyclase
• may be involved in learning, in memory & in drug dependence (putative)
• activated by Ca+2/calmodulin & Gs-alpha[GTP][1]
• activation by Gs-alpha[GTP alone is mild

ATP <--> 3',5'-cyclic AMP + diphosphate

Cofactor: binds 2 Mg+2 per subunit (putative)

Structure

• belongs to the adenylyl cyclase class-4/guanylyl cyclase family
• contains 2 guanylate cyclase domains

Compartment

membrane

Expression

richest source is the hippocampus

More general terms

• adenyl cyclase, adenylyl cyclase or adenylate cyclase
• transmembrane 12 protein

Database

• UniProt: http://www.uniprot.org/uniprot/P40145.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:114
• OMIM: https://mirror.omim.org/entry/103070
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=114