adenyl cyclase-6 (ATP pyrophosphate-lyase 6, ADCY6, KIAA0422)

Function

• membrane-bound, Ca+2-inhibitable adenylyl cyclase
• inhibition by Ca+2 in the submicromolar concentration range (putative)
• activated Gs-alpha[GTP][1]
• inhibited by Ca+2/calmodulin

ATP <--> 3',5'-cyclic AMP + diphosphate

Cofactor: binds 2 Mg+2 per subunit (putative)

Structure

• belongs to the adenylyl cyclase class-4/guanylyl cyclase family
• contains 2 guanylate cyclase domains

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

richest source is the heart

More general terms

• adenyl cyclase, adenylyl cyclase or adenylate cyclase

Database

• OMIM: https://mirror.omim.org/entry/600294
• UniProt: http://www.uniprot.org/uniprot/O43306.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=112