adenyl cyclase-3 (ATP pyrophosphate-lyase 3, adenylyl cyclase 3, adenylate cyclase olfactive type, ADCY3)

Function

• mediates odorant detection (possibly) via modulation of intracellular cAMP concentration
• activated by Ca+2/calmodulin & Gs-alpha[GTP]

ATP <--> 3',5'-cyclic AMP + diphosphate

Cofactor: binds 2 Mg+2 per subunit (putative)

Structure

• belongs to the adenylyl cyclase class-4/guanylyl cyclase family
• contains 2 guanylate cyclase domains

Compartment

membrane

Expression

• expressed in brain, heart, kidney, liver, lung, pancreas, placenta, & skeletal muscle
• richest source is the olfactory neuroepithelium

More general terms

• adenyl cyclase, adenylyl cyclase or adenylate cyclase
• glycoprotein
• transmembrane 12 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:109
• OMIM: https://mirror.omim.org/entry/600291
• UniProt: http://www.uniprot.org/uniprot/O60266.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=109