adenyl cyclase-5 (ATP pyrophosphate-lyase 5, ADCY5)

Function

• membrane-bound, Ca+2-inhibitable adenylyl cyclase
• inhibited by Ca+2/calmodulin
• inhibition by Ca+2 in the submicromolar concentration range (putative)
• activated Gs-alpha[GTP][1]
• protein kinase C & G-beta/gamma have no effect

ATP <--> 3',5'-cyclic AMP + diphosphate

Cofactor: binds 2 Mg+2 per subunit (putative)

Structure

• belongs to the adenylyl cyclase class-4/guanylyl cyclase family
• contains 2 guanylate cyclase domains

Compartment

membrane

Expression

richest source is the caudate

More general terms

• adenyl cyclase, adenylyl cyclase or adenylate cyclase
• transmembrane 12 protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:111
• OMIM: https://mirror.omim.org/entry/600293
• UniProt: http://www.uniprot.org/uniprot/O95622.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=111