autoimmune disease
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Introduction
A disease of autoimmunity.
Pathology
- secretion of IL-17 by T-helper cells (Th17 cells)
- increased serum levels of FCGBP
Laboratory
Complications
Management
- immunosuppression of various forms
- investigational
- in mice, digoxin suppresses production of IL-17 & onset of experimental autoimmune encephalitis[1]
Comparative biology
- antigen-specific immunotherapy appears possible in mice[4]
- type 1 diabetes, experimental autoimmune encephalomyelitis, &/or rheumatoid arthritis treated by creating tiny particles (nanomedicinea) coated by a disease-relevant peptide bound to MHC class II proteins
- this caused generation of regulatory T cells that suppressed both autoantibody & cytotoxic T-cell attack on a specific target
- no evidence of toxicity, including no opportunistic disease or malignancies
- type 1 diabetes, experimental autoimmune encephalomyelitis, &/or rheumatoid arthritis treated by creating tiny particles (nanomedicinea) coated by a disease-relevant peptide bound to MHC class II proteins
More general terms
More specific terms
- acute hemorrhagic leukoencephalopathy
- alopecia areata
- ankylosing spondylitis, axial spondyloarthritis; Marie Strumpell disease; Bechterew's disease (AS)
- anti-glomerular basement membrane [GBM] disease
- anti-IgLON5 disease
- antiphospholipid syndrome (APS); Hughes syndrome
- autoimmune bullous disease (... pemphigus, bullous pemphigoid)
- autoimmune dementia
- autoimmune hemolytic anemia
- autoimmune lymphoproliferative syndrome (ALPS, Canale-Smith syndrome)
- autoimmune pancreatitis; lymphoplasmocytic sclerosing pancreatitis
- autoimmune polyglandular syndrome; autoimmune polyendocrine syndrome
- autoimmune sensorineural hearing loss
- autoimmune thyroid disease (autoimmune thyroiditis)
- autoimmune vasculitis
- Behcet syndrome
- cancer-associated retinopathy syndrome (CAR)
- celiac sprue (gluten-sensitive enteropathy)
- classic polyarteritis nodosa (PAN)
- dermatomyositis
- Evan's syndrome
- graft versus host disease (GVHD)
- granulomatosis with polyangiitis; Wegener's granulomatosis
- Graves disease (Basedow's disease, exothalmic goiter)
- Hashimoto's thyroiditis; chronic lymphocytic thyroiditis; struma lymphomatosa; lymphadenoid goiter; primary myxedema
- IgG4 disease
- immune effector cell-associated neurotoxicity syndrome (ICANS)
- immune or idiopathic thrombocytopenic purpura (ITP)
- immune-mediated necrotizing myopathy (IMNM)
- inflammatory bowel disease
- Kawasaki disease; mucocutaneous lymph node disease
- lymphocytic (autoimmune) hypophysitis
- multiple sclerosis (MS)
- myasthenia gravis
- myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
- paraneoplastic syndrome
- pediatric acute-onset neuropsychiatric syndrome (PANS)
- pernicious anemia
- polymyalgia rheumatica (PMR)
- polymyositis
- primary biliary cirrhosis; primary biliary cholangitis
- psoriasis
- rheumatic fever
- rheumatoid arthritis (RA)
- sarcoidosis
- Schnitzler syndrome
- Sjogren's syndrome (autoimmune epitheliitis)
- Susac syndrome
- systemic lupus erythematosus
- systemic sclerosis
- Takayasu's arteritis; aortic arch syndrome; pulseless disease
- temporal arteritis; cranial arteritis; giant cell arteritis; Horton's disease
- Tn syndrome
- tropical spastic paraparesis
Additional terms
References
- ↑ 1.0 1.1 Huh JR et al Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORt activity. Nature 2011 Apr 28; 472:486 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21441909
Solt LA et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 2011 Apr 28; 472:491 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21499262
Jetten AM. A helping hand against autoimmunity. Nature 2011 Apr 28; 472:421 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21525918 - ↑ Castro C, Gourley M. Diagnostic testing and interpretation of tests for autoimmunity. J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S238-47 PMID: https://www.ncbi.nlm.nih.gov/pubmed/20061009
- ↑ van Assen S, Agmon-Levin N, Elkayam O et al EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2011 Mar;70(3):414-22 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21131643
- ↑ 4.0 4.1 Clemente-Casares X, Blanco J, Ambalavanan P et al. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature 2016 Feb 25; 530:434. PMID: https://www.ncbi.nlm.nih.gov/pubmed/26886799
Wraith D. Antigen-specific immunotherapy. Nature 2016 Feb 25; 530:422 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26886797 - ↑ 5.0 5.1 CPT :accession 81490
- ↑ Conti F, Rezai S, Valesini G. Vaccination and autoimmune rheumatic diseases. Autoimmun Rev 2008 Aug 14; 8:124 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18700175
- ↑ National Institute of Environmental Health Sciences Autoimmune Diseases https://www.niehs.nih.gov/health/topics/conditions/autoimmune/index.cfm