tropical spastic paraparesis
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Etiology
- antibodies against human T-lymphotrophic virus-1 (HTLV-1) tax gene product
Pathology
- autoantibody cross-reacts with hnRNP-A1
- autoantibody stains Betz cells, the target of injury
- autoantibody impairs neuronal firing of Betz cells
More general terms
Additional terms
References
- ↑ Journal Watch 22(12):95, 2002
Levin MC et al Autoimmunity due to molecular mimicry as a cause of neurological disease. Nat Med 8:509, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11984596
Wucherpfennig KW Infectious triggers for inflammatory neurological diseases. Nat Med 8:455, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11984586