heterogeneous nuclear ribonucleoprotein A1; hnRNP core protein A1; helix-destabilizing protein; single-strand RNA-binding protein (HNRNPA1, HNRPA1)

Function

• role in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm & may modulate splice site selection
• Arg-194, Arg-206 & Arg-225 are dimethylated, probably to asymmetric dimethylarginine
• identified in the spliceosome C complex

Structure

contains 2 RRM domain (RNA recognition motif)s

Compartment

• nucleus, cytoplasm
• shuttles continuously between the nucleus & the cytoplasm along with mRNA
• component of ribonucleosomes

Alternative splicing

named isoforms=3

More general terms

• heterogeneous nuclear ribonucleoprotein (hnRNP)
• RNA-binding protein
• phosphoprotein

Component of

• spliceosome C complex

Database

• UniProt: http://www.uniprot.org/uniprot/P09651.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3178
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3178
• OMIM: https://mirror.omim.org/entry/164017