heterogeneous nuclear ribonucleoprotein (hnRNP)

Function

• protein components of complexes of RNA & protein present in the cell nucleus during gene transcription & subsequent post-transcriptional modification of newly synthesized RNA (pre-mRNA), i.e. spliceosome C complex
• binding of hnRNP to a pre-mRNA molecule serves as a signal that the pre-mRNA is not yet fully processed * ready for export to the cytoplasm
• after splicing has occurred, the hnRNP remain bound to spliced introns & target them for degradation

More general terms

• ribonucleoprotein

More specific terms

• heterogeneous nuclear ribonucleoprotein A/B; hnRNP A/B; APOBEC-1-binding protein 1; apolipoprotein B mRNA-editing enzyme catalytic polypeptide 1-binding protein 1; ABBP-1 (HNRNPAB, HNRPAB, ABBP1)
• heterogeneous nuclear ribonucleoprotein A0; hnRNP A0 (HNRNPA0, HNRPA0)
• heterogeneous nuclear ribonucleoprotein A1; hnRNP core protein A1; helix-destabilizing protein; single-strand RNA-binding protein (HNRNPA1, HNRPA1)
• heterogeneous nuclear ribonucleoprotein A3; hnRNP A3 (HNRNPA3, HNRPA3)
• heterogeneous nuclear ribonucleoprotein C-like 1; hnRNP C-like-1; hnRNP core protein C-like 1 (HNRNPCL1, HNRPCL1)
• heterogeneous nuclear ribonucleoprotein C-like 2; hnRNP C-like-2 (HNRNPCL2, HNRNPCP5)
• heterogeneous nuclear ribonucleoprotein C-like 3; hnRNP core protein C-like 3 (HNRNPCL3)
• heterogeneous nuclear ribonucleoprotein D-like; hnRNP D-like; hnRNP DL; AU-rich element RNA-binding factor; JKT41-binding protein; protein laAUF1 (HNRNPDL, HNRPDL, JKTBP)
• heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; AU-rich element RNA-binding protein 1 (HNRNPD AUF1 HNRPD)
• heterogeneous nuclear ribonucleoprotein F; hnRNP F; nucleolin-like protein mcs94-1; contains: heterogeneous nuclear ribonucleoprotein F, N-terminally processed (HNRNPF, HNRPF)
• heterogeneous nuclear ribonucleoprotein G; hnRNP G; RNA-binding motif protein, X chromosome; glycoprotein p43; contains: heterogeneous nuclear ribonucleoprotein G, N-terminally processed (RBMX, HNRPG, RBMXP1)
• heterogeneous nuclear ribonucleoprotein H2; hnRNP H2; FTP-3; heterogeneous nuclear ribonucleoprotein H'; hnRNP H' (HNRNPH2, FTP3, HNRPH2)
• heterogeneous nuclear ribonucleoprotein H3; hnRNP H3; heterogeneous nuclear ribonucleoprotein 2H9; hnRNP 2H9 (HNRNPH3, HNRPH3)
• heterogeneous nuclear ribonucleoprotein H; hnRNP H; contains: heterogeneous nuclear ribonucleoprotein H, N-terminally processed (HNRNPH1, HNRPH, HNRPH1)
• heterogeneous nuclear ribonucleoprotein K; hnRNP K; transformation up-regulated nuclear protein; TUNP (HNRNPK, HNRPK)
• heterogeneous nuclear ribonucleoprotein L-like; hnRNPLL; stromal RNA-regulating factor (HNRNPLL, HNRPLL, SRRF, BLOCK24)
• heterogeneous nuclear ribonucleoprotein L; hnRNP L (HNRNPL HNRPL P/OKcl14)
• heterogeneous nuclear ribonucleoprotein M; hnRNP M (HNRNPM, HNRPM, NAGR1)
• heterogeneous nuclear ribonucleoprotein Q (hnRNP-Q, synaptotagmin-binding cytoplasmic RNA-interacting protein, glycine- & tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1, SYNCRIP, HNRPQ, NSAP1)
• heterogeneous nuclear ribonucleoprotein R; hnRNP R (HNRNPR, HNRPR)
• heterogeneous nuclear ribonucleoprotein U-like protein 1; adenovirus early region 1B-associated protein 5; E1B-55 kDa-associated protein 5; E1B-AP5 (HNRNPUL1, E1BAP5)
• Heterogeneous nuclear ribonucleoprotein U-like protein 2; scaffold-attachment factor A2; SAF-A2 (HNRNPUL2)
• heterogeneous nuclear ribonucleoprotein U; hnRNP U; scaffold attachment factor A; SAF-A; p120; pp120 (HNRNPU, HNRPU, SAFA, U211)
• heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1 (HNRNPA2B1, HNRPA2B1)
• heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1 / hnRNP C2 (HNRNPC, HNRPC)
• RNA-binding protein Raly (hnRNP associated with lethal yellow homolog, autoantigen p542, RALY, P542, Ay protein)