heterogeneous nuclear ribonucleoprotein U; hnRNP U; scaffold attachment factor A; SAF-A; p120; pp120 (HNRNPU, HNRPU, SAFA, U211)

Function

• binds to pre-mRNA
• has high affinity for scaffold-attached region (SAR) DNA
• binds to double-stranded DNA & single-stranded DNA & RNA
• extensively phosphorylated
• Arg-733 & Arg-739 are dimethylated, probably to asymmetric dimethylarginine
• identified in the spliceosome C complex
• ligand for CR2

Structure

• contains 1 B30.2/SPRY domain
• contains 1 SAP domain

Compartment

• nucleus, cell surface
• component of ribonucleosomes
• also found associated with the cell surface

Alternative splicing

named isoforms=2; long, short

More general terms

• heterogeneous nuclear ribonucleoprotein (hnRNP)
• phosphoprotein
• RNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q00839.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3192
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3192
• OMIM: https://mirror.omim.org/entry/602869