heterogeneous nuclear ribonucleoprotein F; hnRNP F; nucleolin-like protein mcs94-1; contains: heterogeneous nuclear ribonucleoprotein F, N-terminally processed (HNRNPF, HNRPF)

Function

• component of heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm
• role in regulation of alternative splicing events
• binds G-rich sequences in pre-mRNAs & keeps target RNA in an unfolded state
• phosphorylated upon DNA damage, probably by ATM or ATR
• sumoylated
• identified in the spliceosome C complex
• interacts with TBP & TXNL4/DIM1

Structure

• the N-terminal RRM domains are responsible for recognizing the G-tract of BCL-X RNA
• contains 3 RRM domains (RNA recognition motifs)

Compartment

nucleus, nucleoplasm

Expression

expressed ubiquitously

More general terms

• heterogeneous nuclear ribonucleoprotein (hnRNP)
• RNA-binding protein
• phosphoprotein

Component of

• spliceosome C complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3185
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3185
• OMIM: https://mirror.omim.org/entry/601037
• UniProt: http://www.uniprot.org/uniprot/P52597.html