TATA-box-binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box factor; transcription initiation factor TFIID TBP subunit; p38TFIID; p38tau (TBP, GTF2D1, TF2D, TFIID)

Function

• subunit of TFIID which binds to TATA box
• binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex, playing a role in activation of eukaryotic genes transcribed by RNA polymerase 2
• binds DNA as monomer
• interacts with TAFs, TFIIB, NCOA6, DRAP1, DR1 & ELF3
• interacts with SPIB, SNAPC1, SNAPC2 & SNAPC4
• interacts with HIV-1 Tat
• interacts with UTF1 which acts as a coactivator of ATF2 transcriptional activity
• interacts with GPBP1 (putative)
• interacts with BRF2

Structure

belongs to the TBP family

Compartment

nucleus

Pathology

• CAG trinucleotide repeat expansion in gene for p38TFIID associated with spinocerebellar ataxia 17

Polymorphism

• the poly-Gln (CAG) region of TBP is highly polymorphic (25-42 repeats) in normal individuals & is expanded to about 47- 63 repeats in spinocerebellar ataxia 17 (SCA17) patients

Laboratory

• TBP gene CAG repeats

More general terms

• transcription factor IID subunit
• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P20226.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6908
• OMIM: https://mirror.omim.org/entry/600075
• OMIM: https://mirror.omim.org/entry/607136
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6908