ETS-related transcription factor Elf-3 (E74-like factor 3, epithelium-specific Ets transcription factor 1, ESE-1, epithelium-restricted Ets protein ESX, epithelial-restricted with serine box, ELF3, ERT, ESX, JEN)

^[1]

Function

transcriptional activator
binds & transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]
synergistic with POU2F3 in transactivating SPRR2A promoter & with RUNX1 to transactivate ANGPT1 promoter
transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 & TGM3 promoters
represses KRT4 promoter activity
role in mediating vascular inflammation
role in epithelial cell differentiation & tumorigenesis
may be a critical downstream effector of the ERBB2 signaling pathway
may be associated with mammary gland development & involution
role in regulation of transcription with TATA-less promoters in preimplantation embryos, essential in preimplantation development
interacts with TBP
interacts with CREBBP & EP300
- these act as transcriptional coactivators of ELF3 & positively modulate its function
interacts with XRCC5/KU86 & XRCC6/KU70
- these inhibit the ability of ELF3 to bind DNA & negatively modulate its transcriptional activity
associated with CLND7 & POU2F3

cytoplasm, nucleus
localizes to cytoplasm where it transforms MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism
transiently expressed & localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A & MCF-12A (transcription-dependent)

expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach & skin
transcriptionally regulated by ERBB2 receptor signaling in breast cancer epithelial cells
up-regulated by phorbol-12-myristate-13-acetate in bronchial epithelial cells
up-regualted by retinoic acid in MCF-7 mammary epithelial cells