C-C motif chemokine 20; beta-chemokine exodus-1; CC chemokine LARC; liver & activation-regulated chemokine; macrophage inflammatory protein 3 alpha; MIP-3-alpha; small-inducible cytokine A20 (CCL20, LARC, MIP3A, SCYA20)

Function

• chemotactic factor that attracts lymphocytes &, to lesser extent, neutrophils
• not chemotactic for monocytes
• inhibits proliferation of myeloid progenitors in colony formation assays
• may be involved in formation & function of mucosal lymphoid tissues by attracting lymphocytes & dendritic cells towards epithelial cells
• C-terminal processed forms have equal chemotactic activity for leukocytes
• antibacterial activity E coli ATCC 25922 & S aureus ATCC 29213
• C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes
• binds to & activates CCR6

Structure

• belongs to the intercrine beta (chemokine CC) family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, & fetal lung
• low expression in thymus, prostate, testis, small intestine & colon
• induced by bacterial lipopolysaccharides (LPS), TNF zzzzzzzzzzzzz7 IFN-gamma
• induced by phorbol myristate acetate (PMA) in U937 cell line & Bowes melanoma
• repressed by IL-10

More general terms

• CC chemokine; beta chemokine

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6364
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6364
• OMIM: https://mirror.omim.org/entry/601960
• UniProt: http://www.uniprot.org/uniprot/P78556.html