keratin, type II cytoskeletal 8; cytokeratin-8; CK-8; keratin-8; K8 (KRT8 CYK8)

Function

• Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle
• phosphorylation on Ser is enhanced during EGF stimulation & mitosis
• Ser-74 phosphorylation plays a role in keratin filament reorganization
• keratin-8 associates with keratin-18
• associates with KRT20
• when associated with KRT19, interacts with DMD
• interacts with TCHP
• interacts with HCV core protein & PNN

Structure

• O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues
• heterotetramer of 2 type 1 & 2 type 2 keratins
• belongs to the intermediate filament family

Compartment

cytoplasm

Expression

• observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin & spectrin
• expressed in gingival mucosa & hard palate of the oral cavity

Pathology

• defects in KRT8 are a cause of cryptogenic cirrhosis
• diagnostic pathology: recognized by CAM 5.2 antibody

More general terms

• cytokeratin, epithelial keratins or soft alpha-keratins
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3856
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3856
• OMIM: https://mirror.omim.org/entry/148060
• OMIM: https://mirror.omim.org/entry/215600
• UniProt: http://www.uniprot.org/uniprot/P05787.html