small proline-rich protein 2A; SPR-2A; 2-1 (SPRR2A)
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Function
- cross-linked envelope protein of keratinocytes
- keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase; this results in the formation of an insoluble envelope beneath the plasma membrane
Structure
belongs to the cornifin (SPRR) family
Compartment
Expression
- expressed during squamous differentiation of epidermal keratinocytes