pinin (140 kD nuclear & cell adhesion-related phosphoprotein, domain-rich serine protein, DRS-protein, DRSP, melanoma metastasis clone A protein, desmosome-associated protein, SR-like protein, nuclear protein SDK3, PNN, DRS, MEMA)
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Function
- transcriptional activator
- binds to E-box 1 core sequence 5'CAGGTG-3' of the E-cadherin promoter gene
- reverses CTBP1-mediated transcription repression.
- regulation of alternative pre-mRNA splicing.
- associates to spliced mRNA within 60 nucleotides upstream of the 5' splice sites
- establishment & maintenance of epithelia cell-cell adhesion
- forms complex with SR proteins
- found in a mRNP complex with RNPS1
- interacts with C6orf111/SRRP130, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 & SRRM2
- component of spliceosome C complex
Compartment
- nucleus, nuclear speckle
- cell junction, cell membrane,
- desmosome of intercellular adherens junction (cell-cell contact)
- not a nucleocytoplasmic shuttling protein
Alternative splicing
named isoforms=2
Expression
- expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, epidermis, esophagus, brain, smooth muscle, skeletal muscle
Pathology
- tumor suppressor for renal cell carcinoma (putative)
- expressed strongly in melanoma metastasis lesions & advanced primary tumors