serine/arginine repetitive matrix protein 2 (serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kD, Ser/Arg-related nuclear matrix protein, SR-related nuclear matrix protein of 300 kD, splicing coactivator subunit SRm300, 300 kD nuclear matrix antigen, SRRM2, KIAA0324, SRL300, SRM300, HSPC075)

Function

• component of pre- & post-splicing multiprotein mRNP complexes
• role in pre-mRNA processing events
• binds to RNA
• component of active spliceosome
• found in a SRRM/SFRS/SNRP pre-mRNA splicing complex
• identified in the spliceosome C complex

Structure

belongs to the CWC21 family

Compartment

nucleus, nuclear speckle

Alternative splicing

named isoforms=3

Expression

expressed in liver, placenta, white blood cells

More general terms

• RNA-binding protein
• nuclear protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606032
• UniProt: http://www.uniprot.org/uniprot/Q9UQ35.html