RNA-binding protein with serine-rich domain 1; SR-related protein LDC2 (RNPS1, LDC2)

Function

• component of pre- & post-splicing multiprotein mRNP complexes
• enhances the formation of the ATP-dependent A complex of spliceosome
• involved in both constitutive splicing & with SRP54 & SFRS10
• modulation of alternative splicing in a substrate-dependent manner
• participates in mRNA 3'end cleavage
• involved in RENT2-dependent nonsense-mediated decay of mRNAs containing premature stop codons
• mediates increase of mRNA abundance & translational efficiency
• binds spliced mRNA 20-25 nt upstream of exon-exon junctions
• component of the active spliceosome.
• associates with polysomes
• found in a mRNA splicing-dependent exon junction complex
• found in a post-splicing complex
• phosphorylated on one or more of 4 Ser/Thr (S43, T49, S52, S53)
  • S53 phosphorylation stimulates splicing activity in vitro
• interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 & TRA2B/SFRS10

Structure

• belongs to the splicing factor SR family
• contains 1 RRM domain (RNA recognition motif

Compartment

• nuclear speckles & cytoplasmic
• nucleocytoplasmic shuttling

Expression

ubiquitous

More general terms

• nuclear protein
• phosphoprotein

Component of

• post-splicing multiprotein complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10921
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10921
• OMIM: https://mirror.omim.org/entry/606447
• UniProt: http://www.uniprot.org/uniprot/Q15287.html