cyclin-dependent kinase 11B; cell division cycle 2-like protein kinase 1; CLK-1; cell division protein kinase 11B; galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1; p58 CLK-1 (CDK11B, CDC2L1, CDK11, PITSLREA, PK58)

Function

• appears to play multiple roles in cell cycle progression, cytokinesis & apoptosis
• the p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7
• the p58 isoform may act as a negative regulator of normal cell cycle progression
• the cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1 & RANBP9
• the cleaved p110 isoform interacts with RNPS1
• the p58 isoform but not the p110 isoforms or p110C interacts with CCND3
• the p110 isoforms are found in high molecular weight complexes containing CCNL1 & SFRS7
• phosphorylation at Thr-448 or Tyr-449 inactivates CDC2L1
• phosphorylation at Thr-595 activates CDC2L1 (putative)
• during apoptosis, induced by Fas or tumor necrosis factor,
• specific PITSLRE p110 isoforms are cleaved by caspases to produce a protein (p110C) that contains the C-terminal kinase domain of the PITSLRE proteins
• P110C can be autophosphorylated

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
• contains 1 protein kinase domain

Compartment

cytoplasm. nucleus

Alternative splicing

named isoforms=10

Alternative initiation

yes

Expression

• expressed ubiquitously
• some evidence of isoform-specific tissue distribution
• p58 isoform is specifically induced in G2/M phase of the cell cycle

Genetics

• duplicated gene
• CDC2L1 & CDC2L2 encode almost identical protein kinases of 110 kD that contain at their C termini the open reading frame of a smaller 58 kD isoform which is expressed following IRES-mediated alternative initiation of translation

Notes

• also see CDK11A
• many references talk about 'p110 isoforms' but it is not yet known if this refers to CDC2L1 &/or CDC2L2 or one/some of the isoforms of each

More general terms

• serine/threonine kinase

Additional terms

• cell division protein kinase 11A; PITSLRE serine/threonine protein kinase CDC2L2; cell division cycle 2-like protein kinase 2; galactosyltransferase-associated protein kinase p58/GTA (CDK11A, CDC2L2, CDC2L3, PITSLREB)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=984
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:984
• OMIM: https://mirror.omim.org/entry/176873
• UniProt: http://www.uniprot.org/uniprot/P21127.html