Ran-binding protein M; Ran-binding protein 9; RanBP9; BPM-L; BPM90; RanBPM; RanBP7 (RANBP9, RANBPM)

Introduction

One of two Ran-binding protein 9. Importin-9 is the other.

Function

• may act as an adapter protein to couple membrane receptors to intracellular signaling pathways
• may be involved in signaling of ITGB2/LFA-1 & other integrins
• enhances HGF-MET signaling by recruiting Sos & activating the Ras pathway
• enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1
• does not affect estrogen-induced transactivation
• stabilizes TP73 isoform alpha, probably by inhibiting its ubiquitination, & increases its proapoptotic activity
• inhibits kinase activity of DYRK1A & DYRK1B
• inhibits FMR1 binding to RNA
• phosphorylated upon DNA damage, probably by ATM or ATR
• phosphorylated in response to stress
• can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C)
• ubiquitinated
• polyubiquitination targets the protein for rapid degradation
• can be deubiquitinated by USP11
• interacts with NGFR & DDX4 (putative)
• interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1, S100A7, USP11, MKLN1, SOS1 or SOS2, C20orf11, & FMR1
• interacts with the Dyrk kinases HIPK2, DYRK1A, & DYRK1B
• interacts with TP73 isoform alpha
• does not interact with TP53
• interacts with the HGF receptor MET & the integrins ITGB1 & ITGB2
• does not interact with ITGAL
• part of a complex consisting of RANBP9, MKLN1 & C20ORF11
• part of a complex consisting of RANBP9, RAN, DYRK1B & COPS5
• directly interacts with RANBP10

Structure

• the SPRY domain mediates the interaction with MET, AR, & CDC2L1
• belongs to the RANBP9/10 family
• contains 1 B30.2/SPRY domain
• contains 1 CTLH domain
• contains 1 LisH domain

Compartment

• cytoplasm, nucleus
• predominantly cytoplasmic
• phosphorylated form is associated with the plasma membrane

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed
• highest expession in testes, placenta, heart, & muscle
• lowest expression in lung
• within the brain, expressed predominantly by neurons in
  • gray matter of cerebral corte
  • cerebellar granular layer
  • Purkinje cells

More general terms

• cytoskeletal protein
• phosphoprotein

Additional terms

• importin 9 (Ran-binding protein 9, RanBP9, HSPC273, IPO9, IMP9, KIAA1192)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10048
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10048
• OMIM: https://mirror.omim.org/entry/603854
• UniProt: http://www.uniprot.org/uniprot/Q96S59.html