CD18 (integrin beta-2, L-CAM beta, ITGB2, CD18, MFI7)

Function

• forms complexes with
  • CD11a (integrin alpha-L)
  • CD11b (integrin alpha-M)
  • CD11c (integrin alpha-X)
  • integrin alpha-D
• interacts with COPS5 & RANBP9
• both Ser-745 & Ser-756 become phosphorylated when T-cells are exposed to phorbol esters
• phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins

Structure

• belongs to the integrin beta chain family
• contains 1 VWFA domain

Compartment

membrane

Expression

leukocytes

Pathology

• defects are associated with leukocyte adhesion deficiency type 1

More general terms

• integrin-beta
• CD antigen

Component of

• lymphocyte function-associated antigen-1 (LFA-1, leukocyte adhesion protein LFA-1, integrin alpha-L/beta-2, CD11a/CD18)
• integrin alpha-D/beta-2 (CD11d/CD18)
• integrin alpha-X/beta-2 (CD11c/CD18)
• integrin alpha-M/beta-2 (CD11b/CD18, MAC1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3689
• OMIM: https://mirror.omim.org/entry/116920
• OMIM: https://mirror.omim.org/entry/600065
• UniProt: http://www.uniprot.org/uniprot/P05107.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3689