CD11d; integrin alpha-D; leukointegrin alpha D; ADB2; CD11 antigen-like family member D (ITGAD)

Function

• component of integrin alpha-D/beta-2 (CD11d/CD18)

Structure

• the integrin I-domain (insert) is a VWFA domain
• integrins with I-domains do not undergo protease cleavage
• belongs to the integrin alpha chain family
• contains 7 FG-GAP repeats
• contains 1 VWFA domain

Compartment

membrane

Expression

• strongly expressed on tissue-specialized cells
  • macrophages foam cells within atherosclerotic plaques
  • splenic red pulp macrophages (erythrophagocytosis)
• moderately expressed on
  • myelomonocytic cell lines
  • subsets of peripheral blood leukocytes

More general terms

• CD11

Component of

• integrin alpha-D/beta-2 (CD11d/CD18)

Database

• OMIM: https://mirror.omim.org/entry/602453
• UniProt: http://www.uniprot.org/uniprot/Q13349.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3681