CD11a; integrin alpha-L; leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; leukocyte function-associated molecule 1 alpha chain; CD11 antigen-like family member A (ITGAL, CD11A)
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Function
- component of integrin alpha-L/beta-2 (CD11a/CD18)
- forms complex with CD18
- binds to CD54 & CD102
Structure
- the integrin I-domain (insert) is a VWFA domain.
- integrins with I-domains do not undergo protease cleavage
- belongs to the integrin alpha chain family
- contains 7 FG-GAP repeats
- contains 1 VWFA domain
Compartment
membrane
Alternative splicing
named isoforms=2
Expression
- all leukocytes
- platelets stain negatively with antibody.
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P20701.html
- ↑ Hibbs ML, Xu H, Stacker SA, Springer TA. Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit. Science. 1991 Mar 29;251(5001):1611-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1672776
- ↑ Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 165
- ↑ http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3683