CD102; intercellular adhesion molecule 2; ICAM-2 (ICAM2)
Jump to navigation
Jump to search
Function
- ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2
- mediates adhesive interactions important for
- antigen-specific immune response
- NK-cell mediated clearance
- lymphocyte recirculation via blocking LFA-1-dependent cell adhesion
- other immune response & surveillance functions
- adhesion of leukocytes to endothelium during inflammation
Structure
- belongs to the immunoglobulin superfamily, ICAM family
- contains 2 Ig-like C2-type domain (immunoglobulin-like)
Compartment
membrane
Expression
- constitutively expressed on surface of endothelial cells, lymphocytes, monocytes, platelets
- some lymphomas
- neutrophils stain negatively with antibody
More general terms
Additional terms
References
- ↑ Akella R, Hall RE. Expression of the adhesion molecules ICAM-1 and ICAM-2 on tumor cell lines does not correlate with their susceptibility to natural killer cell-mediated cytolysis: evidence for additional ligands for effector cell beta integrins. Eur J Immunol. 1992 Apr;22(4):1069-74. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1348028
- ↑ Verbeek MM, Otte-Holler I, Westphal JR, Wesseling P, Ruiter DJ, de Waal RM. Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease. Am J Pathol. 1994 Jan;144(1):104-16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7904796
- ↑ UniProt http://www.uniprot.org/uniprot/P13598.html
- ↑ http://www.pathologyoutlines.com/cd100247.html 21 June 2005
- ↑ Functional glycomics gateway - glycan binding; Note: ICAM-2 http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_262