lymphocyte function-associated antigen-1 (LFA-1, leukocyte adhesion protein LFA-1, integrin alpha-L/beta-2, CD11a/CD18)
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Function
- receptor for ICAMs (ICAM1, ICAM2, ICAM3 & ICAM4)
- role in a variety of immune phenomena including:
- leukocyte-endothelial cell interaction (adhesion)
- cytotoxic T-cell mediated killing
- antibody-dependent killing by granulocytes & monocytes
- cytoskeletal reorganization (putative)
Structure
- consists of:
Pathology
- defects associated with LFA-1 immunodeficiency disease
Pharmacology
- LFA-1 antagonist lifitegrast (Xiidra) ophthalmic FDA-approved for treatment of xerophthalmia
More general terms
Additional terms
- CD102; intercellular adhesion molecule 2; ICAM-2 (ICAM2)
- intercellular adhesion molecule 1; ICAM-1; major group rhinovirus receptor; CD54 (ICAM1)
- intercellular adhesion molecule 3; ICAM-3; ICAM-R; CDw50; CD50 (ICAM3)
- LFA-1 immunodeficiency disease
- lifitegrast (Xiidra)
References
- ↑ UniProt http://www.uniprot.org/uniprot/P13598.html
- ↑ Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
- ↑ Kelleher D, Murphy A, Cullen D. Leukocyte function-associated antigen 1 (LFA-1) is a signaling molecule for cytoskeletal changes in a human T cell line. Eur J Immunol. 1990 Oct;20(10):2351-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2242762
- ↑ Hibbs ML, Xu H, Stacker SA, Springer TA. Regulation of adhesion of ICAM-1 by the cytoplasmic domain of LFA-1 integrin beta subunit. Science. 1991 Mar 29;251(5001):1611-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1672776
- ↑ FDA News Release. July 12, 2016 FDA approves new medication for dry eye disease http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm510720.htm