intercellular adhesion molecule 1; ICAM-1; major group rhinovirus receptor; CD54 (ICAM1)
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Function
- ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)
- role in adhesion of leukocytes to endothelium during inflammation.
- during leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF & RHOG activation
- monoubiquitinated, which is promoted by MARCH9 & leads to endocytosis
- interacts with MUC1 & promotes cell aggregation in epithelial cells
- interacts with SGEF
Structure
- homodimer (probable)
- MW depends upon degree of glycosylation
- belongs to the immunoglobulin superfamily, ICAM family
- contains 5 Ig-like C2-type domain (immunoglobulin-like)
Compartment
membrane
Expression
- B & T cells
- monocytes
- endothelial cells
- normally expressed in low levels on cerebral endothelial cells
- epithelial cells
- expression induced by IL-1, IL-6, IFN-gamma, TNF
Pathology
- major group rhinovirus receptor
- interacts with human herpesvirus 8 MIR2 protein (probable)
- binds to coxsackievirus A21 capsid proteins & acts as a receptor for this virus
- accumulates in senile plaques of Alzheimer's disease
Polymorphism
- homozygotes with ICAM1-kalifi Met-56 seem to have an increased risk for cerebral malaria
More general terms
References
- ↑ Akella R, Hall RE. Expression of the adhesion molecules ICAM-1 and ICAM-2 on tumor cell lines does not correlate with their susceptibility to natural killer cell-mediated cytolysis: evidence for additional ligands for effector cell beta integrins. Eur J Immunol. 1992 Apr;22(4):1069-74. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1348028
- ↑ Verbeek MM, Otte-Holler I, Westphal JR, Wesseling P et al Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease. Am J Pathol. 1994 Jan;144(1):104-16. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/7904796
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3383
- ↑ Wikipedia; Note: intercellular adhesion molecule entry http://en.wikipedia.org/wiki/intercellular_adhesion_molecule
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/icam1/
- ↑ virus particle exploreR db; Note: Icosahedral capsid structure http://viperdb.scripps.edu/info_page.php?VDB=1z7z
- ↑ Functional glycomics gateway - glycan binding; Note: ICAM-1 http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_261
- ↑ UniProt http://www.uniprot.org/uniprot/P05362.html