interleukin-1; lymphocyte-activating factor (IL1)

Function

• involved in the inflammatory response,
  • endogenous pyrogen
  • stimulates the release of prostaglandin & collagenase from synovial cells

Compartment

• secreted
• the lack of a specific hydrophobic segment in the precursor suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins

Expression

• secreted by monocytes, macrophages, endothelial cells, fibroblasts & keratinocytes

More general terms

• interleukin
• monokine
• secreted peptide without leader

More specific terms

• interleukin-1 alpha; IL-1 alpha; hematopoietin-1 (IL1A, IL1F1)
• interleukin-1 beta; IL-1 beta; catabolin (IL1B, IL1F2)
• interleukin-1 family member
• interleukin-1 theta; interleukin-1 family member 10; IL-1F10; FIL1 theta; interleukin-1 HY2; IL-1HY2; IL-1 theta (IL1F10, FIL1T, IL1HY2, FKSG75, UNQ6119/PRO20041)
• interleukin-1-like protein 1; interleukin-36 receptor antagonist protein; FIL1 delta; IL-1-related protein 3; IL-1RP3; interleukin-1 HY1; IL-1HY1; interleukin-1 delta; IL-1 delta; interleukin-1 family member 5; IL-1F5; interleukin-1 receptor antagonist...

Additional terms

• canakinumab (Ilaris)
• interleukin-1 receptor (IL1R)
• interleukin-1 [IL-1] binding protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?