interleukin-1-like protein 1; interleukin-36 receptor antagonist protein; FIL1 delta; IL-1-related protein 3; IL-1RP3; interleukin-1 HY1; IL-1HY1; interleukin-1 delta; IL-1 delta; interleukin-1 family member 5; IL-1F5; interleukin-1 receptor antagonist homolog 1; IL-1ra homolog 1; IL-1L1 (IL36RN, FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, UNQ1896/PRO4342)

Function

• specific antagonist of the IL-1 receptor-related protein 2- mediated response to interleukin 1 family member 9 (IL1F9)
• could constitute part of an independent signaling system analogous to IL-1 alpha (IL-1A), IL-1 beta (IL-1B) receptor agonist & interleukin-1 receptor type 1 (IL1R1), that is present in epithelial barriers & takes part in local inflammatory responses

Structure

belongs to the IL-1 family

Compartment

secreted

Expression

• predominantly expressed in keratinocytes
• not expessed in fibroblasts, endothelial cells or melanocytes
• detected in spleen, brain leukocyte & macrophage cell types
• increased expression in lesional psoriasis skin
• induced by phorbol ester (PMA) & bacterial lipopolysaccharides (LPS) treatment in macrophage cell line

Pathology

• defects in IL36RN are the cause of generalized pustular psoriasis

More general terms

• interleukin-1; lymphocyte-activating factor (IL1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26525
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26525
• OMIM: https://mirror.omim.org/entry/605507
• OMIM: https://mirror.omim.org/entry/614204
• UniProt: http://www.uniprot.org/uniprot/Q9UBH0.html