interleukin-36 gamma; IL-1-related protein 2; IL-1RP2; interleukin-1 epsilon; IL-1 epsilon; interleukin-1 family member 9; IL-1F9; interleukin-1 homolog 1; IL-1H1 (IL36G, IL1E, IL1F9, IL1H1, IL1RP2, UNQ2456/PRO5737)

Function

• agonist of NF-kappa B activation through the orphan IL1RL2
• could constitute part of an independent signaling system analogous to IL-1 alpha, IL-1 beta & IL1R1, present in epithelial barriers & takes part in local inflammatory response

Structure

belongs to the IL-1 family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• highly expressed in tissues containing epithelial cells: skin, lung, stomach & esophagus
• in skin, expressed only in keratinocytes
  • not expressed in fibroblasts, endothelial cells or melanocytes
• induced by TNF & by IFNG/IFN-gamma in keratinocytes

Pathology

• up-regulated in lesional psoriasis skin

More general terms

• interleukin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56300
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56300
• OMIM: https://mirror.omim.org/entry/605542
• UniProt: http://www.uniprot.org/uniprot/Q9NZH8.html