CDw121A, interleukin-1 receptor type I; IL-1R-1; IL-1RT1; IL-1R-alpha; p80; CD121 antigen-like family member A; CD121a (IL1R1, IL1RA, IL1RT1)
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Function
- receptor for:
- binding of ligand leads to the activation of NF-kappa-B
- signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, & IRAK1 or IRAK2
- binds IL1RAP
Structure
- belongs to the interleukin-1 receptor family
- contains 3 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 TIR domain
Compartment
membrane
More general terms
- interleukin-1 receptor (IL1R)
- immunoglobulin superfamily protein
- CD antigen
- glycoprotein
- phosphoprotein
References
- ↑ UniProt http://www.uniprot.org/uniprot/P14778.html
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/il1r1/
- ↑ O'Neill LA, Bird TA, Gearing AJ, Saklatvala J. Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). J Biol Chem. 1990 Feb 25;265(6):3146-52. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2154471
- ↑ Colotta F et al Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science. 1993 Jul 23;261(5120):472-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8332913