interleukin-1 receptor antagonist protein; IL-1ra; IL-1RN; IRAP; IL1 inhibitor; ICIL-1RA (IL1RN, IL1F3, IL1RA)
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Function
- inhibits the activity of IL-1 by binding to its receptor
- has no IL-1 like activity
- has anti-inflammatory properties
- secreted normally during inflammatory response
- inhibits LPS-mediated stimulated production of:
- inhibits synthesis of IgE
Compartment
Alternative splicing
named isoforms=4
Expression
- the intracellular form of IL1RN is predominantly expressed in epithelial cells
Pathology
- SNP in IL-1RN associated with increased severity of osteoarthritis[8]
Pharmacology
- available under the name anakinra (Kineret from Amgen)
- used for treatment of moderately to severely active rheumatoid arthritis
More general terms
More specific terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P18510.html
- ↑ R&D systems' cytokine source book: IL-1ra http://www.rndsystems.com/molecule_detail.aspx?m=1637
- ↑ Wikipedia; interleukin-1 entry http://en.wikipedia.org/wiki/interleukin_1
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/il1rn/
- ↑ SHMPD; The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1RN
- ↑ Kineret professional medical information http://www.kineretrx.com/professional/
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ 8.0 8.1 Wu X, Kondragunta V, Kornman KS et al IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort. Osteoarthritis Cartilage. 2013 Apr 18. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23602982