granulocyte-macrophage colony-stimulating factor; GM-CSF; colony-stimulating factor 2; molgramostin; sargramostim (CSF2, GMCSF)

Function

• cytokine that stimulates growth & differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils & erythrocytes
• activation of endothelial cells

Structure

• monomer
• belongs to the GM-CSF family

Compartment

secreted

Polymorphism

• variant Ile-117 may be a risk factor for atopic asthma

Pharmacology

• available as sargramostim (Leukine, Leucomax)

More general terms

• colony-stimulating factor (CSF)
• glycoprotein

More specific terms

• sargramostim [GM-CSF] (Leukine, Prokine, Leucomax)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1437
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1437
• OMIM: https://mirror.omim.org/entry/138960
• UniProt: http://www.uniprot.org/uniprot/P04141.html