interleukin-1 receptor associated kinase 2 (IRAK2)

Function

• binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation & mRNA stabilization
• interacts with MYD88
• IL-1 stimulation leads to formation of a signaling complex which dissociates from the IL-1 receptor following binding of PELI1

Structure

• Asn-335 is present instead of the conserved Asp which is expected to be an active site residue
• protein kinase domain is predicted to be catalytically inactive
• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
• contains 1 death domain
• contains 1 protein kinase domain

Expression

• expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas & peripheral blood leukocytes

More general terms

• interleukin-1 receptor associated kinase (IRAK)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3656
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3656
• OMIM: https://mirror.omim.org/entry/603304
• UniProt: http://www.uniprot.org/uniprot/O43187.html