myeloid differentiation primary response protein MyD88 (MYD88)

Function

• myeloid differentiation (putative)
• mediator in NF kappa B signaling (putative)
• increases level of IL-8 transcription (putative)
• involved in the Toll-like receptor & IL-1 receptor signaling pathway in the innate immune response
• acts via IRAK1, IRAK2, IRF7 & TRAF6, leading to NF-kappa-B activation, cytokine secretion & the inflammatory response
• role in IL-18-mediated signaling pathway
• forms heterodimers with TIRAP
• binds to TLR2, TLR4, IRAK1, IRAK2 & IRAK4 via their respective TIR domains
• interacts with IL18R1 (putative)
• interacts with IL1RL1
• interacts with IRF7

Structure

• homodimer
• the intermediate domain (ID) is required for phosphorylation & activation of IRAK (putative)
• contains 1 death domain
• contains 1 TIR domain

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• ubiquitous
• widely expressed except skeletal muscle & brain

Pathology

• defects in MYD88 are the cause of MYD88 deficiency
• mutations associated with lymphoblastic lymphoma

Laboratory

• MYD88 gene p.Leu265Pro mutation

More general terms

• other protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4615
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4615
• OMIM: https://mirror.omim.org/entry/602170
• OMIM: https://mirror.omim.org/entry/612260
• UniProt: http://www.uniprot.org/uniprot/Q99836.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?