interleukin-8; IL-8; C-X-C motif chemokine 8; monocyte-derived neutrophil chemotactic factor; MDNCF; T-cell chemotactic factor; neutrophil-activating protein 1; NAP-1; protein 3-10C; Granulocyte chemotactic protein 1; GCP-1; monocyte-derived neutrophil-activating peptide; MONAP; emoctakin; lymphocyte-derived neutrophil-activating factor; LYNAP; neutrophil-activating factor; leukocyte adhesion inhibitor; NAF; MDNCF-c (IL8, CXCL8)

Function

• chemotactic factor that attracts neutrophils, basophils, & T-cells, but not monocytes
• role in neutrophil activation
• mediates transendothelial neutrophil migration
• mitogenic for endothelial cells
• released from several cell types in response to an inflammatory stimulus
• IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation & IL-8(7-77) has a higher affinity to receptors CXCR1 & CXCR2 as compared to IL-8(1-77)
• several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes & endothelial cells

Structure

• homodimer
• belongs to the intercrine alpha (chemokine CxC) family
• in general, IL-8(1-77) is referred to as interleukin-8
• IL-8(6-77) is the most promiment form

Compartment

secreted

Alternative splicing

named isoforms=2

Pathology

• elevated in pancreatic exocrine secretion with pancreatitis, but does not distinguish from pancreatic cancer

More general terms

• interleukin
• sis family protein
• CXC chemokine; alpha chemokine
• monokine

Additional terms

• interleukin-8 receptor (IL8 receptor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3576
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3576
• OMIM: https://mirror.omim.org/entry/146930
• UniProt: http://www.uniprot.org/uniprot/P10145.html