high affinity interleukin-8 receptor B; IL-8R B; CXCR-2; GRO/MGSA receptor; IL-8 receptor type 2; CDw128b; CD182 (IL8RB, CXCR2)

Function

• receptor for interleukin-8
• binding of IL-8 causes activation of neutrophils
• response is mediated via a G-protein that activates a phosphatidylinositol-Ca+2 second messenger system
• binds to IL-8 with high affinity
• also binds with high affinity to CXCL3, GRO/MGSA & NAP-2
• phosphorylated upon ligand binding; which is required for desensitization

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

More general terms

• interleukin-8 receptor (IL8 receptor)
• CXC chemokine receptor
• phosphoprotein
• CD antigen

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3579
• OMIM: https://mirror.omim.org/entry/146928
• UniProt: http://www.uniprot.org/uniprot/P25025.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3579