growth-regulated alpha protein; C-X-C motif chemokine 1; GRO-alpha(1-73); melanoma growth stimulatory activity; MGSA; neutrophil-activating protein 3; NAP-3; contains: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73) (CXCL1, GRO, GRO1, GROA, MGSA, SCYB1)

Function

• MGSA binds to IL-8 receptor-beta
• does not bind IL-8 receptor-alpha
• chemotactic for neutrophils
• may play a role in inflammation
• exerts autocrine effects on endothelial cells
• N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) & GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes
• in vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) & GRO-alpha(6-73) show a 30-fold higher chemotactic activity than CXCL1

Structure

• belongs to the intercrine alpha (chemokine CxC) family

Compartment

secreted

Comparative biology

• MGSA is the protein product of gro (human) or KC (mouse) gene

More general terms

• gro proto-oncogene protein
• CXC chemokine; alpha chemokine

Additional terms

• high affinity interleukin-8 receptor B; IL-8R B; CXCR-2; GRO/MGSA receptor; IL-8 receptor type 2; CDw128b; CD182 (IL8RB, CXCR2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2919
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2919
• OMIM: https://mirror.omim.org/entry/155730
• UniProt: http://www.uniprot.org/uniprot/P09341.html