high affinity interleukin-8 receptor A; IL-8R A; IL-8 receptor type 1; CXCR-1; CDw128a; CD181 (IL8RA, CMKAR1, CXCR1)

From Aaushi

Jump to navigation Jump to search

^[1]^[2]^[3]^[4]

Function

receptor to interleukin-8
binding of IL-8 to the receptor causes activation of neutrophils
response is mediated via a G-protein that activate a phosphatidylinositol-Ca+2 second messenger system
binds to IL-8 with a high affinity & to MGSA (GRO) with low affinity

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

More general terms

References

↑ UniProt http://www.uniprot.org/uniprot/P25024.html
↑ Wikipedia; CXC chemokine receptors entry http://en.wikipedia.org/wiki/CXC_chemokine_receptors
↑ SeattleSNPs http://pga.gs.washington.edu/data/il8ra/
↑ Wu D et al G protein-coupled signal transduction pathways for interleukin-8. Science 261:101 1993 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8316840

Database

Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3577
OMIM: https://mirror.omim.org/entry/146929
UniProt: http://www.uniprot.org/uniprot/P25024.html
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3587

Retrieved from "https://aaushi.info/w/index.php?title=A143632&oldid=1056038"

↑ Back to top