C-X-C motif chemokine 3; GRO-gamma(1-73); growth-regulated protein gamma; GRO-gamma; macrophage inflammatory protein 2-beta; MIP2-beta; contains: GRO-gamma(5-73) (CXCL3, GRO3, GROG, SCYB3)

Function

• ligand for CXCR2 (putative)
• chemotactic for neutrophils
• may play a role in inflammation
• may have autocrine effects on endothelial cells
• N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes
  • in vitro, GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophils than CXCL3

Structure

• belongs to the intercrine alpha (chemokine CxC) family

Compartment

secreted

More general terms

• CXC chemokine; alpha chemokine
• gro proto-oncogene protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2921
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2921
• OMIM: https://mirror.omim.org/entry/139111
• UniProt: http://www.uniprot.org/uniprot/P19876.html