Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282 (TLR2, TIL4)
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Function
- cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins & other microbial cell wall components (peptigoglycan, Pan-3)
- acts via MyD88 & TRAF6
- NF-kappa-B activation
- cytokine secretion
- inflammatory response
- promotes apoptosis in response to lipoproteins (putative)
- recognizes pathogen antigens cooperatively with TLR6
- mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2)
- soluble tuberculosis factor (STF)
- phenol-soluble modulin (PSM)
- B. burgdorferi outer surface protein A lipoprotein (OspA-L)
- binds LY96, TLR2 & TLR6 via the extracellular domain
- binds MyD88 via their respective TIR domains
- interacts with TICAM1.
- ligand binding induces the formation of a heterodimer with TLR1
Structure
- glycosylation of Asn-442 involved in secretion of N-terminal ectodomain
- belongs to the Toll-like receptor family
- contains 14 LRR repeats (leucine-rich repeats)
- contains 1 TIR domain
Compartment
membrane
Expression
- expressed in peripheral blood leukocytes, especially monocytes, bone marrow, lymph node, spleen > lung, fetal liver
Polymorphism
- genetic variations in TLR2 are associated with suceptibility to leprosy
- Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy
- wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae- dependent activation of NFKB1, but TLR2 containing the Trp-677 polymorphism des not
- impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy