toll/IL-1 receptor homologous region (TIR domain)

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Introduction

Cytoplasmic domain of approximately 200 amino acids found in Toll receptors & ILR1, involved in innate antibacterial & antifungal immunity. It mediates homotypic protein-protein interactions in signal transduction & directs localization of receptor(s) through interaction(s) with the cytoskeleton (putative).

Proteins containing a TIR domain include:

More general terms

Additional terms

References

  1. Prosite :accession PS50104
  2. Kopp et al. Genes & Dev 13:2059-71, 1999